Thursday, May 2, 2013

Cell response to new coronavirus unveils possible paths to treatments

Wednesday, May 1, 2013

NIH-supported scientists used lab-grown human lung cells to study the cells' response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection. The information about host response to nCoV allowed the researchers to predict drugs that might be used to inhibit either the virus itself or the deleterious responses that host cells make in reaction to infection. Since nCoV was recognized in 2012, 17 confirmed cases and 11 deaths have been reported?a high fatality rate that is spurring urgent research efforts to better understand the virus and its effects.

The investigators, led by Michael G. Katze, Ph.D., of the University of Washington, compared cellular gene expression responses to two viruses: the novel coronavirus and a coronavirus that caused a global outbreak of severe acute respiratory syndrome (SARS) in 2003. Although the viruses are in the same family, their effects on human cells are vastly different. In general, nCoV disrupted a greater number of human genes more profoundly and at more time points after infection than the SARS coronavirus. The team identified one set of 207 human genes whose expression differed from normal soon after infection with nCoV and remained disrupted throughout the course of infection. Notably, nCoV down-regulated the activity of a group of genes involved in signaling the presence of an invading virus to the immune system. Such down-regulation may cause a delay in the infection-fighting response.

The researchers used computational approaches to determine that certain classes of drugs, including specific kinase inhibitors and one type of glucocorticoid, act on some of the 207 human genes whose expression was found to be disrupted by nCoV. The team hypothesized that treatment with such drugs might block nCoV replication and disease progression in the host. In their current study, they tested this hypothesis using a kinase inhibitor on nCoV-infected cells grown in test tubes. They found that the drug did inhibit the ability of the virus to replicate. Additional studies are needed to see if kinase inhibitors could be useful alone or in combination with other drugs to treat nCoV infection in people.

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L Josset et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio DOI: 10.1128/mBio.00165-13 (2013) (http://mbio.asm.org/content/4/3/e00165-13).

NIH/National Institute of Allergy and Infectious Diseases: http://www.niaid.nih.gov

Thanks to NIH/National Institute of Allergy and Infectious Diseases for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128055/Cell_response_to_new_coronavirus_unveils_possible_paths_to_treatments

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Wednesday, May 1, 2013

Zinc: The Goldilocks metal for bioabsorbable stents?

Apr. 30, 2013 ? In 2012, more than 3 million people had stents inserted in their coronary arteries. These tiny mesh tubes prop open blood vessels healing from procedures like a balloon angioplasty, which widens arteries blocked by clots or plaque deposits. After about six months, most damaged arteries are healed and stay open on their own. The stent, however, is there for a lifetime.

Most of the time, that's not a problem, says Patrick Bowen, a doctoral student studying materials science and engineering at Michigan Technological University. The arterial wall heals in around the old stent with no ill effect. But the longer a stent is in the body, the greater the risk of late-stage side effects. For example, a permanent stent can cause intermittent inflammation and clotting at the implant site. In a small percentage of cases, the tiny metal segments that make up the stent can break and end up poking the arterial wall.

"When the stent stays in place 15, 20 or 25 years, you can see these side effects," says Bowen. "It's not uncommon to have a stent put in at age 60, and if you live to be 80, that's a long time for something to remain inert in your body."

That's why researchers are trying to develop a bioabsorbable stent, one that would gradually -- and harmlessly -- dissolve after the blood vessel is healed.

Many studies have investigated iron- and magnesium-based stents. However, iron is not promising: it rusts in the artery. Magnesium, on the other hand, dissolves too quickly. "We wondered, 'Isn't there something else?'" Bowen said. "And we thought, 'Why not zinc?'"

So they placed tiny zinc wires in the arteries of rats. The results were amazing. "The corrosion rate was exactly where it needed to be," Bowen said. The wires degraded at a rate just below 0.2 millimeters per year -- the "magic" value for bioabsorbable stents -- for the first three months. After that, the corrosion accelerated, so the implant would not remain in the artery for too long. On top of that, the rats' arteries appeared healthy when the wires were removed, with tissue firmly grasping the implant.

"Plus, zinc reduces atherosclerosis," he added, referring to zinc's well-known ability to fight the development of plaque in the arteries. "How cool is that? A zinc stent might actually have health benefits."

There is one drawback. "A stent made of conventional zinc would not be strong enough to hold open a human artery," he said. "We need to beef it up, double the strength."

"The good news is that there are commercial zinc alloys that are up to three times stronger," Bowen said. "We know we can get there. We just don't want to ruin our corrosion behavior."

The researchers have filed a provisional patent on their discoveries and are now testing new zinc-based stent materials.

An article on their work, "Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents," was recently published in the journal Advanced Materials.

Bowen's research is supported by a two-year, $52,000 predoctoral fellowship from the American Heart Association. Initial research was supported by a summer fellowship from the DeVlieg Foundation.

Bowen's advisor is Jaroslaw Drelich, a professor of materials science and engineering, and they work in close collaboration with Jeremy Goldman, an associate professor of biomedical engineering. Undergraduates Jacob Braykovich and Matt Tianen are also working on material development and corrosion testing related to the project.

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The above story is reprinted from materials provided by Michigan Technological University. The original article was written by Marcia Goodrich.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Patrick K. Bowen, Jaroslaw Drelich, Jeremy Goldman. Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents. Advanced Materials, 2013; DOI: 10.1002/adma.201300226

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/heart_disease/~3/0zyu7mRzULY/130430194409.htm

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Syria's Assad in rare visit as rockets hit capital

In this photo released by the Syrian official news agency SANA, President Bashar Assad, center, visits the Umayyad Electrical Station on May Day, a day after a powerful bomb hit the capital. in Damascus, Syria, Wednesday, May 1, 2013. (AP Photo/SANA)

In this photo released by the Syrian official news agency SANA, President Bashar Assad, center, visits the Umayyad Electrical Station on May Day, a day after a powerful bomb hit the capital. in Damascus, Syria, Wednesday, May 1, 2013. (AP Photo/SANA)

In this photo released by the Syrian official news agency SANA, President Bashar Assad, center right, visits the Umayyad Electrical Station on May Day, a day after a powerful bomb hit the capital. in Damascus, Syria, Wednesday, May 1, 2013. (AP Photo/SANA)

In this photo released by the Syrian official news agency SANA, President Bashar Assad, left, visits the Umayyad Electrical Station on May Day, a day after a powerful bomb hit the capital. in Damascus, Syria, Wednesday, May 1, 2013. (AP Photo/SANA)

FILE - In this Monday, Sept. 17, 2012 file photo, Hezbollah leader Sheik Hassan Nasrallah, center, waves to his supporters, in the southern suburb of Beirut, Lebanon. The leader of Lebanon?s Hezbollah says Syrian rebels will not be able to defeat President Bashar Assad?s regime, while strongly suggesting his Iranian-backed militant group could intervene on the government?s side if the need arises. (AP Photo/Hussein Malla, File)

(AP) ? Syrian President Bashar Assad made a rare public appearance at a Damascus power station on Wednesday, while two bombs exploded near the city center, killing one and wounding over two dozen people, Syria's state news agency reported.

Footage of the visit broadcast on state television showed Assad chatting casually with a group of employees, two days after his prime minister narrowly escaped assassination by an explosion and a day after another major bombing in the capital took the lives of at least 14.

SANA said a 10-year-old boy was killed and 28 people wounded, some seriously, in Wednesday's attack, when bombs went off in Khaled Bin Walid street and the nearby Bab Mesalla square. It said the bombs were planted by "terrorists," a term the government uses to describe rebels fighting to topple the Syrian leader.

The Britain-based Syrian Observatory for Human Rights said the Bab Mesalla explosion was near a police station and came from rocket fire. It said the blast left casualties but did not have figures on dead or wounded. It also said that several people, including children, were wounded in the explosion in Khaled Bin Walid street.

Police had sealed off Bab Mesalla, which has restaurants, shops and a main public transportation station linking Damascus with the southern provinces of Daraa and Sweida, the Observatory added.

In the capital's western neighborhood of Mazzeh, two people were killed when a bomb attached to a bicycle went off, SANA said. On Monday, a bomb exploded as Prime Minister Wael Halqi's convoy drove by in the same neighborhood.

Assad's visit to the Umayyad Electrical Station in the Tishrin Park district came on International Workers Day, or May Day. State TV showed the Syrian leader, confident and wearing a dark business suit, addressing the station's staff and later shaking their hands. Similar still images also appeared on a page used by the Syrian presidency on the popular social network Facebook.

"They want to scare us, we will not be scared ... They want us to live underground, we will not live underground," Assad told a group of workers who had gathered around him. "We hope that by this time next year we will have overcome the crisis in our country," he said.

Tuesday's blast was the second in the heart of the capital in two days. Rebels seeking to topple Assad have been trying to create a supply line from Jordan, so that arms bought by Saudi Arabia and Qatar can be shipped in for assaults on the city they hope to capture.

Meanwhile, the Egypt-based Syrian National Coalition rebuked the leader of Lebanon's Hezbollah militant group, in its first public response a day after he said that Syrian rebels will not be able to defeat Assad's regime militarily.

Sheik Hassan Nasrallah had warned that Syria's "real friends," including his Iranian-backed militant group, could intervene on the government's side if the need arises.

The coalition said it hoped Hezbollah would stay out of the Syrian war, and urged Lebanon to "control its borders and urgently stop, through all available means, the military operations attributed to Hezbollah in areas close to the Syrian border."

It also blamed Assad's regime for "destroying" religious Muslim and Christian sites.

Hezbollah, a powerful Shiite Muslim group, is known to be backing Syrian government forces in Shiite villages near the Lebanese border against the mostly Sunni rebels fighting to topple Assad. But Nasrallah's comments were the strongest indication yet that his group is ready to intervene more substantially on the side of Assad's embattled regime.

"You will not be able to take Damascus by force and you will not be able to topple the regime militarily. This is a long battle," Nasrallah said, addressing the Syrian opposition. "Syria has real friends in the region and in the world who will not allow Syria to fall in the hands of America or Israel or the Takfiris."

Takfiris is a term used to refer to followers of an al-Qaida-like extremist ideology.

Hezbollah and Iran are close allies of Assad. Rebels have accused both of them of sending fighters to assist Syrian troops trying to crush the 2-year-old anti-Assad uprising, which the U.N. says has killed more than 70,000 people.

____

Associated Press writers Albert Aji in Damascus and Zeina Karam in Beirut contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-05-01-Syria/id-af92357fa7ce4e1688e7d2b34ced8a85

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Italy's Letta wins confidence vote after pledging growth drive

By James Mackenzie

ROME (Reuters) - Italy's new Prime Minister Enrico Letta won his first vote of confidence in parliament on Monday after promising to press for a change to the European Union's focus on austerity and pursue economic growth and jobs.

Letta said Italy could not afford to focus simply on trying to cut its huge public debt and needed a new emphasis on lifting the economy out of recession.

The confidence motion in his right-left coalition government easily passed as expected, by 453 votes to 153 in the Chamber of Deputies, the lower house.

Letta was backed by his own centre-left Democratic Party (PD), Silvio Berlusconi's centre-right People of Freedom (PDL) party as well as centrists led by former prime minister Mario Monti. The government will be fully empowered after a second vote in the Senate on Tuesday.

However, the first opinion poll published since his cabinet was announced, conducted by the EMG agency, gave Letta an approval rating of just 41 percent, showing that many Italians are unconvinced by the coalition of former adversaries.

Just 13 percent of Italians said they wanted Letta as prime minister, suggesting he may struggle to obtain the honeymoon period usually enjoyed by new governments. Monti began his government with approval ratings as high as 70 percent.

"We will die of fiscal consolidation alone, growth policies cannot wait any longer," Letta said in his speech to the Chamber of Deputies, describing the country's economic situation as still "serious" after more than a decade of stagnation.

POSITIVE REACTION

Financial market reaction to Letta's appointment and the end of months of political stalemate in the euro zone's third largest economy has been positive, with bond yields falling and shares rising.

Italy's cost of borrowing dropped to its lowest since October 2010 at an auction of mid and long term bonds.

Letta, a 46-year-old moderate with strong contacts outside Italy, pledged to stick to Rome's budget commitments to its European Union partners, announcing he would visit Brussels, Paris and Berlin this week.

He joined the growing numbers of European politicians attacking the former consensus on budget austerity but offered few specific proposals about how to restore growth to Italy's economy, which has shrunk below the level it was in 2001.

"We all have the clear and strong feeling that our destiny will be the destiny we want only if the choices Europe makes are different from the choices made up to now," he said.

Stefano Fassina, the PD's main economic spokesman, said Letta should renegotiate Italy's budget target to gain more breathing room. "Other countries have done it and so should we," he said in parliament.

Letta was pushed into a coalition with Berlusconi after the centre-left fell short of a viable parliamentary majority in February's inconclusive election, which left no side with the numbers to govern alone.

Berlusconi, who is fighting legal battles over a tax fraud conviction and charges of paying for sex with a minor, will not be in cabinet but will exercise a powerful influence behind the scenes, to the disgust of many on the left who find the idea of working with their old enemy abhorrent.

POINTS OF CONFLICT

In a speech that ranged from tax to constitutional reform and touched on issues including tourism, prisons and two Italian marines at the centre of a diplomatic standoff with India, Letta avoided points of conflict between members of his coalition.

He made no reference to a law tackling conflicts of interests, which was promised by his PD party before and after the election but would be unacceptable to media tycoon Berlusconi, who has staked a claim to chair a special commission examining institutional reforms.

Responding to centre-right demands for an unpopular housing tax to be scrapped, Letta said payments due in June would be halted although he did not promise to abolish the tax altogether as Berlusconi has demanded.

He hoped a planned increase in sales tax, which would see the main rate rise from 21 percent to 22 percent in July, could be delayed and said payroll taxes that dissuaded companies from hiring should be lowered.

He did not indicate how he would pay for tax changes, which together with proposed measures to extend unemployment protection would require as much as 10 billion euros ($13 billion) in 2013.

The current electoral law, which contributed heavily to the inconclusive election result in February would be changed before the next election and he proposed a special commission to consider other political and constitutional reforms.

(Additional reporting by Catherine Hornby, Gavin Jones, Steve Scherer, Naomi O'Leary; Editing by Giles Elgood)

Source: http://news.yahoo.com/italys-letta-government-begins-life-climate-crisis-050501937.html

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Tsarnaev homeland Chechnya: rebuilt from war, ruled by fear

By Maria Golovnina

GROZNY, Russia (Reuters) - When it was last in the international spotlight, Chechnya was in ruins, its capital Grozny reduced to dust by the deadliest artillery and air onslaught in Europe since World War Two.

Today, when the naming of two Chechens as suspects in the Boston Marathon bombings has put it back on the world's front pages, Chechnya appears almost miraculously reborn.

The streets have been rebuilt. Walls riddled with bullet holes are long gone. New high rise buildings soar into the sky. Spotless playgrounds are packed with children. A giant marble mosque glimmers in the night.

Yet, scratch the surface and the miracle is less impressive than it seems. Behind closed doors, people speak of a warped and oppressive place, run by a Kremlin-imposed leader through fear.

The heavily guarded skyscrapers of the newly built Grozny City complex are windswept and empty. At night, the streets are deserted.

Dzhokhar and Tamerlan Tsarnaev's ethnic homeland, a mainly Muslim province that saw centuries of war and repression, no longer threatens to secede from Russia. But it has become breeding ground for a form of militant Islam whose adherents have spread violence to other parts of Russia, and may have inspired the radicalization of the Boston bombers.

"It may look like it's stable and peaceful but it's really not the case," said a human rights campaigner, who, like others daring to express any criticism of the Moscow-backed Chechen leader, Ramzan Kadyrov, asked that her name not be used.

There are still fragmented groups of rebel fighters in the mountains, the activist added. "And there are young people in the villages who go out and join them, who take food to the mountains."

SUSHI, IPHONES AND ISLAM

Moscow has poured billions of roubles into Chechnya to rebuild it. It boasts that there is no longer any trace of the separatist insurgency that humiliated the Russian army in battles in the 1990s.

On top of what was once the rubble of Grozny's central Minutka Square - where an armored column of Russian forces was nearly wiped out in street fighting in January 1995 - there are now slick cafes where young men in leather jackets and women in headscarves eat sushi and tap on their iPhones.

Kadyrov, a 36-year-old former rebel, peers down from billboards and out from TV newscasts. A red neon slogan declares "Ramzan, thank you for Grozny!"

A stocky man with a neatly trimmed beard and intense grey eyes, he cultivates an image as a devout Muslim and family man, fond of posting snapshots on Internet photo service Instagram.

He loves a good party, especially when he is the guest of honor. In 2011 he hired singer Seal and Hollywood stars Jean-Claude Van Damme and Hilary Swank to appear at his birthday jubilee. After human rights groups complained, Swank apologized, fired her manager and gave her six-figure fee to charity.

Kadyrov and his authorities deny they are involved in abuse, murders or disappearances. But his critics have a long history of dying in unsolved murders or disappearing without a trace.

Human rights groups have linked Kadyrov to the murders of Russian opposition-minded journalist Anna Politkovskaya, Chechen exiles in Austria and Turkey, and rival Chechen clan chiefs shot dead in Moscow and Dubai, all cases in which he denies involvement.

Russian human rights activist Natalya Estemirova was abducted in Grozny in 2009 and later found dead. Rights groups list the names of up to 5,000 Chechens who are still missing.

Kadyrov's office said he was not available for interview.

His loyalty can be embarrassing even for the Kremlin. At the last elections, President Vladimir Putin and his ruling United Russia party won more than 99 percent of Chechnya's vote, with Soviet-style turnout over 99 percent.

Grozny's central thoroughfare is now named after Putin.

"What's happening here is absurd. It's George Orwell, 1984," said a dissident who asked that his identity not be revealed. "Nothing is going to change here any time soon. Chechen spring? Forget about it."

GOLDEN CHANDELIER

In Grozny, passersby freeze and stare with a mixture of fear and awe when Kadyrov's noisy motorcade glides through the city.

His closest allies drive luxury sedans with tinted windows and distinctive "KRA" number plates - his initials: "Kadyrov, Ramzan Akhmatovich".

Kadyrov's father Akhmad Kadyrov was a former rebel mufti who was put in charge of Chechnya by Putin and ruled it until he was assassinated in 2004. A museum to the elder Kadyrov sports Russia's biggest chandelier, weighing 1.5 metric tons (1.65 tons) and containing 22 kg (48 pounds) of gold. It was made in Iran.

Perhaps in an attempt to limit the influence of Islamist rebels by co-opting religion, Kadyrov has banned alcohol and gambling, and promoted polygamy and headscarves for women. A few years ago, his supporters were seen firing paintball guns at women whose clothes were deemed insufficiently modest.

Yet Kadyrov's promotion of Islam has not dimmed the appeal of the radical version espoused by fighters led by Doku Umarov, a Chechen former pro-independence guerrilla commander who leads an Islamist revolt focused mainly on neighboring Dagestan.

"When they tell us that only this official form of Islam is allowed, obviously everyone is going to question it," said the rights campaigner. "People don't like to be lectured on how to be faithful."

DEVOTION AND RESENTMENT

As in Soviet times, it is impossible to say what Chechens truly think of their leader. When questioned in public, residents reply with stock phrases of devotion.

"I don't know what would have happened to us without our leader," said Fatima Magomedova, 44, a heavily veiled flower shop worker. "We are free now."

Many are no doubt sincere in their admiration for Kadyrov, who has brought peace and relative prosperity after a decade of war killed tens of thousands of people, mainly civilians.

"I don't think many people want to leave. In fact, a lot of Chechens say they want to come back. Those who are leaving are those who are after an easy life," said Khamza Khirakhmatov, a deputy to Chechnya's official spiritual leader.

"Those who want to achieve something, a certain success, are only coming back, getting jobs, getting involved in projects to promote morality and spirituality and help our republic."

But outside the glitzy city center lies an impoverished country where joblessness is close to 80 percent in some regions. Many flock to Grozny in search of work, but complain that jobs are reserved for those in Kadyrov's clan.

"It's very hard. There is almost no work. I've been out of work for years. All the main construction sites are operated by Ramzan's people and it's impossible to get a job there because everyone wants to work there," said Lyoma, a man from the town of Urus-Martan, waiting for work on the side of the road with other unemployed laborers from around Chechnya.

Outside Grozny, Chechens survive off small-scale agriculture in villages scattered across a fertile belt between the capital and the towering, snow-capped Caucasus mountains to the south.

"People live off farming. They eat what they grow," said Yusup, a local resident in the mountain village of Itum-Kale perched in a steep river valley near Chechnya's border with Georgia. "It's beautiful here but there is no work for young people."

Others dream of leaving.

Rukiyat Arsayeva went to Grozny to apply for a passport in the hope of travelling to Europe. She said she was seeking medical help for her two daughters.

One, now 14, was a toddler when she was wounded in the abdomen by a Russian air strike. The other, now 20, was made deaf as a child by a missile blast.

Their mother said she feared the Boston bombings would make it harder for Chechens to get visas to escape to the West.

"Chechens are now going to be seen as bad people. We are not terrorists. After what happened I don't know what kind of treatment to expect there," she said nervously, clutching her paperwork on a dusty street outside the passport office.

"What happened in Boston is very bad. I am a small person. All I want is to help my children."

(Editing by Peter Graff)

Source: http://news.yahoo.com/tsarnaev-homeland-chechnya-rebuilt-war-ruled-fear-065446773.html

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Scientists reach the ultimate goal -- controlling chirality in carbon nanotubes

Tuesday, April 30, 2013

An ultimate goal in the field of carbon nanotube research is to synthesise single-walled carbon nanotubes (SWNTs) with controlled chiralities. Twenty years after the discovery of SWNTs, scientists from Aalto University in Finland, A.M. Prokhorov General Physics Institute RAS in Russia and the Center for Electron Nanoscopy of Technical University of Denmark (DTU) have managed to control chirality in carbon nanotubes during their chemical vapor deposition synthesis.

Carbon nanotube structure is defined by a pair of integers known as chiral indices (n,m), in other words, chirality.

Chirality defines the optical and electronic properties of carbon nanotubes, so controlling it is a key to exploiting their practical applications, says Professor Esko I. Kauppinen, the leader of the Nanomaterials Group in Aalto University School of Science.

Over the years, substantial progress has been made to develop various structure-controlled synthesis methods. However, precise control over the chiral structure of SWNTs has been largely hindered by a lack of practical means to direct the formation of the metal nanoparticle catalysts and their catalytic dynamics during tube growth.

We achieved an epitaxial formation of Co nanoparticles by reducing a well-developed solid solution in CO, reveals Maoshuai He, a postdoctoral researcher at Aalto University School of Chemical Technology.

For the first time, the new catalyst was employed for selective growth of SWNTs, adds senior staff scientist Hua Jiang from Aalto University School of Science.

By introducing the new catalysts into a conventional CVD reactor, the research team demonstrated preferential growth of semiconducting SWNTs (?90%) with an exceptionally high population of (6,5) tubes (53%) at 500 ?C. Furthermore, they also showed a shift of the chiral preference from (6,5) tubes at 500 ?C to (7, 6) and (9, 4) nanotubes at 400 ?C.

These findings open new perspectives both for structural control of SWNTs and for elucidating their growth mechanisms, thus are important for the fundamental understanding of science behind nanotube growth, comments Professor Juha Lehtonen from Aalto University.

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The research has been recently published in a new Nature Publishing Group journal Scientific Reports, 3 (2013), 1460.

Link to article: http://www.nature.com/srep/2013/130315/srep01460/full/srep01460.html

Aalto University: http://www.aalto.fi/en/

Thanks to Aalto University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128019/Scientists_reach_the_ultimate_goal____controlling_chirality_in_carbon_nanotubes

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Google Now comes to iPhone, iPad; challenges Apple's Siri

San Francisco: Google Inc is bringing its Google Now technology to the iPhone, where it will compete head-on with Apple Inc's Siri to serve as the primary service that smartphone users rely on to get everything from weather updates to traffic forecasts.

Google Now, which made its debut last year on mobile devices powered by Google's Android operating system, will be available as a feature in the new version of the Google Search app for iPhones and iPads starting on Monday.

Personal assistant technology such as Apple's Siri, Google Now and products created by various start-up companies aspire to play what could become a critical role on smartphones by helping users with daily chores such as looking up information on the Web, handling calendar appointments and managing travel plans.

Google Now comes to iPhone, iPad; challenges Apple\'s Siri

The technology taps into Google\'s various online services to deliver relevant information throughout the day in pop-up windows.

Some analysts believe Apple's Siri, which comes pre-loaded on iPhones and iPads, represents a growing threat to Google, the world's No. 1 search engine. The information that Siri provides on common topics such as sports scores and nearby restaurants reduces the need to visit Google's search engine, the analysts say.

Johanna Wright, Google's vice president of Search and Assist for Mobile, described Google Now as the next phase in the evolution of search, in which answers are served up without a user needing to type in a query.

The technology taps into Google's various online services, from Web search to personal Gmail email and Google Calendar entries, to deliver relevant information throughout the day in pop-up windows that Google refers to as "cards." By accessing an email with a flight itinerary, for example, Google Now can automatically remind a traveler about an upcoming trip and suggest the best time to leave for the airport based on current traffic conditions.

Unlike the Android version of Google Now, in which users can swipe the phone's homescreen to quickly access the pop-up cards, the version for Apple's iOS will only display these cards when a user has opened the Google Search app.

The smartphone has emerged as a key battleground between Google and Apple as consumers increasingly access the Web with mobile devices instead of personal computers.

In September, Apple replaced the Google Maps app that once came pre-loaded on iPhones with a new maps app that Apple created in-house. The Apple maps service contained embarrassing errors, drawing fierce criticism from consumers and reviewers and forcing Apple Chief Executive Tim Cook to offer a public apology.

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