Potential new drug target in Lou Gehrig's disease

ScienceDaily (Nov. 14, 2011) ? Two proteins conspire to promote a lethal neurological disease, according to a study published online this week in the Journal of Experimental Medicine.

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that results in progressive loss of motor function and ultimately death. More than 90% of ALS cases have no known genetic cause or family history. However, in some patients, spinal cord cells contain unusual accumulations of a protein called TDP-43.

Jean-Pierre Julien and colleagues at Laval University in Quebec now find that TDP-43 binds to an inflammatory protein called NF-kB p65 in the spinal cords of ALS patients but not of healthy individuals. TDP-43 and p65 were also more abundant in ALS than healthy spinal cords. In spinal cord cells called microglia, TDP-43 and p65 cooperated to ramp up production of factors capable of promoting inflammation and killing nearby neurons. In a mouse model of ALS, treatment with an agent capable of blocking p65 activity minimized neuron loss and eased disease symptoms.

These findings highlight p65 as a potential therapeutic target for this debilitating disorder.

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The above story is reprinted from materials provided by Rockefeller University Press, via Newswise.

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Journal Reference:

1. Vivek Swarup, Daniel Phaneuf, Nicolas Dupr?, Susanne Petri, Michael Strong, Jasna Kriz, and Jean-Pierre Julien. Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor ?B?mediated pathogenic pathways. Journal of Experimental Medicine, 2011 DOI: 10.1084/jem.20111313

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111114133630.htm

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